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PROTECTION OF PATIENTS LACKING A FUNCTIONAL SPLEEN AGAINST S. PNEUMONIAE WITH PNEUMOCOCCAL SURFACE PROTEIN A (PspA)
PROTECTION OF PATIENTS LACKING A FUNCTIONAL SPLEEN AGAINST S. PNEUMONIAE WITH PNEUMOCOCCAL SURFACE PROTEIN A (PspA)
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机译:肺炎链球菌表面蛋白A(PspA)保护缺乏肺炎链球菌功能性脾脏的患者
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摘要
The present invention relates to a method of treating Streptococcus pneumoniae infection in a subject lacking a functional spleen. This method involves administering to the subject lacking a functional spleen an antibody that recognizes pneumococcal surface protein A (PspA) or a binding portion thereof under conditions effective to treat Streptococcus pneumoniae infection in the subject. The present invention also relates to a method of immunization against Streptococcus pneumoniae infection in a subject lacking a functional spleen. This method involves administering to the subject lacking a functional spleen PspA or a fragment thereof under conditions effective to elicit immunity that can prevent Streptococcus pneumoniae infection in the subject.
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