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Anti-connective tissue type mast cells antibodies and hybridomas which produce the antibodies
Anti-connective tissue type mast cells antibodies and hybridomas which produce the antibodies
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机译:抗结缔组织型肥大细胞抗体和产生该抗体的杂交瘤
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摘要
The invention is related to antibodies which specifically react with connective tissue type-human mast cells, a production method of the antibodies, hybridomas which produce the antibodies, a production method of the hybridomas and antigen proteins recognized by the antibodies. After cord blood cells were cultured in the presence of SCF and IL-6, they were further cocultured with primary culture of human skin fibroblasts, and connective tissue type-human mast cells were thus obtained. A rat was immunized using the cells, hybridomas were prepared and selected by an ordinary method, and novel monoclonal antibodies were harvested from the culture supernatant of the selected hybridomas. The monoclonal antibodies specifically reacted with connective tissue type-human mast cells.
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