USE OF SIRNAS FOR GENE SILENCING IN ANTIGEN PRESENTING CELLS

摘要

The invention relates to the use of siRNAS for the down regulation of target genes in antigen presenting cells, in particular dendritic cells. Preferred target genes are those encoding the NF-λB subunits p50 and c-Rel, or the TNF-receptor associated factor 3. The invention is useful in particular in immunosuppressive therapies.