PROCESS AND SUPPORTS FOR SYNTHESIS OF PEPTIDES COMPRISING A THIOESTER OR THIOACID

摘要

A process for the Fmoc synthesis of a peptide comprising a thioester or thioacid which comprises removing the Nα-Fmoc blocking group with a base selected from optionally substituted piperazine or optionally substituted 2,6-C1-4dialkyl-piperidine or a mixture thereof. Also novel solid supports suitable for the solid-state synthesis of peptide thioesters and thioacids and processes for making these supports.