CRYSTAL STRUCTURE OF 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE SYNTHASE IN COMPLEX WITH INHIBITORS

摘要

The invention relates to a new crystal which comprises the protein 2C-methyl-D-erythritol 4-phosphate synthase (IspC). Further the crystal structure of IspC in complex with metal ions and a bound inhibitor is provided. Moreover, methods of identifying new inhibitors of IspC are described.