The role of the N-myc - nm23H1/nm23H2 - cdc42 pathway in proliferation, differentiation and treatment of cancer

摘要

The invention relates to a method for the treatment of cancer by changing the intracellular activity of cdc42. The activity can be increased by treatment with small molecules, for instance treatment with non-hydrolyzable GTP-analogues of cdc-42. Also the activity can be increased by the inhibition of nm23-H1 and/or nm23-H2 which are factors which have an inhibitory effect on the expression and/or activity of cdc-42. It is also shown in the present invention that a decreasin the intracellular activity of cdc-42 has a beneficial effect.;Further embodiments of the invention are the compounds for use in such methods, pharmaceutical preparations comprising such compounds and use of such compounds for the preparation of a medicament for treatment of cancer.