Cross-beta structure pathway and its therapeutic relevance

摘要

The invention relates to cross-β structures and the biological role of these cross-β structures. Methods for modulating extracellular protein degradation and/or protein clearance or for diminishing plaques involved in conformational diseases by modulating cross-β structure formation and/or tissue plasminogen activator (tPA)-like activity are disclosed, as well as diagnostic methods by visualising cross-β structures.