IDENTIFICATION AND TARGETING OF CONSENSUS SITES BY WHICH DYNORPHIN EXERTS ITS NEUROTOXIC EFFECTS ENABLES ANALGESIA WITHOUT NEUROTOXICITY

摘要

Molecular decoyants are provided for the treatment of an organism which has been subjected to a dynorphin which exerts a neurotoxic effect only after first binding to an endogenous NMDA receptor and which exerts an analgesic effect only after first binding to an endogenous opioid receptor, the treatment being for the reduction of the neurotoxic effect without preventing the analgesic effect, having a chemical structure which functionally resembles the ligand binding site of the endogenous NMDA receptor for the dynorphin, and which does not functionally resemble the ligand binding site of the endogenous opioid receptor for the dynorphin.