MICROEMULSION PRECONCENTRATES WHICH CONTAIN CYCLOSPORINES AND CORRESPONDING MICROEMULSIONS

摘要

The invention relates to compositions provided in the form of microemulsion preconcentrates containing: (a) a mixture consisting of a medium chain triglyceride and of an omega-9-fatty acid and/or of an omega-6-fatty acid, and; (b) a surface-active constituent containing a surfactant of the polyoxethylene type; however, containing essentially none of the following constituents which can be mixed with water or which are soluble in water: C1-C5 alkyl diether or tetrahydrofurfuryl diether or partial ether of low-molecular monooxy or polyoxy C2-C12 alkane diols; 1,2-propylene glycol; low alkanols; esterification products or polycarboxylic acids with 2-10, especially 3-5 carboxyl groups with C1-C10 alcohols, and; esterification products of polyols with 2-10, especially 3-5 carboxyl groups with C2-C11 carboxylic acids. These microemulsion preconcentrates form microemulsions when brought into contact with water or with an aqueous medium, whereby those of the O/W type have an average particle size of less than 150 nm, preferably of less than 100 nm. The inventive microemulsion preconcentrates and microemulsions are suited for use as a vehicle for substances, namely active substances, which are poorly soluble in water but, however, are soluble in constituents (a) and/or (b). In their water-phase, said microemulsions can contain water-soluble substances.