Thiourea carbonic anhydrase inhibitors and their use in treatment of glaucoma

摘要

Carbonic anhydrase inhibitory compounds which incorporate a 4-sulfamoylphenylmethylthiourea scaffold are disclosed. The new compounds show strong affinities toward carbonic anhydrase isozymes I, II and IV and produce effective and prolonged reduction in intraocular pressure following topical ocular administration. The compounds are useful in treating glaucoma or ocular hypertension.