首页> 外国专利> FISH DNA CHIPS FOR ENVIRONMENTAL STRESS ANALYSIS AND METHOD OF ENVIRONMENTAL HARMFULNESS ANALYSIS THERETHROUGH

FISH DNA CHIPS FOR ENVIRONMENTAL STRESS ANALYSIS AND METHOD OF ENVIRONMENTAL HARMFULNESS ANALYSIS THERETHROUGH

机译:用于环境应力分析的鱼类DNA芯片和环境危害性分析方法

摘要

PURPOSE: Fish DNA chips for analysis of environmental stress and an analysis method of environmental harmfulness using the same are provided, thereby sensitively and accurately analyzing the environmental stress and harmfulness. CONSTITUTION: Fish DNA chips for analysis of environmental stress consists of Orzyias latipes gene groups specifically binding to environmental harmful materials, wherein the Orzyias latipes gene groups comprise (a) an estrogenic potential relating gene group, (b) a biotoxicity relating gene group, (c) a cancer causing gene group and (d) a living body development relating gene group; the estrogenic potential relating gene is selected from cytochrome p450, heat shock 70, endothelin receptor, guanyl cyclase and stromyselin-3; the cancer causing gene is selected from v-fos, arrestin, ras-2-protooncogene, p53, apoptosis RVP1, V-myc and retinoblastoma; and the living body development relating gene is selected from beta-actin, developmental transcription factor, glutathione-S-transferase and cyclin 2.
机译:目的:提供用于分析环境压力的鱼类DNA芯片和使用该DNA芯片的环境危害分析方法,从而灵敏而准确地分析环境压力和危害。组成:用于分析环境压力的鱼类DNA芯片由与环境有害物质特异性结合的拉希米氏菌基因组组成,其中拉希米氏菌基因组包括(a)雌激素潜能相关基因组,(b)生物毒性相关基因组,( c)致癌基因组和(d)与生物体发育有关的基因组;雌激素潜能相关基因选自细胞色素p450,热休克70,内皮素受体,鸟苷酸环化酶和stromyselin-3。致癌基因选自v-fos,抑制蛋白,ras-2-原癌基因,p53,凋亡RVP1,V-myc和成视网膜细胞瘤。活体发育相关基因选自β-肌动蛋白,发育转录因子,谷胱甘肽-S-转移酶和细胞周期蛋白2。

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