NEW TETRAHYDROISOQUINOLINE ENANTIOMER COMPOUND AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

摘要

PURPOSE: A tetrahydroisoquinoline-based compound, a pharmaceutically acceptable salt or prodrug thereof having optical activity are provided which are useful as remedies for sepsis, cardiac stimulants, antihypertensive agents, antithrombotic agents, antiinflammatory agents, DIC treating agents and cardiac insufficiency treating agents. CONSTITUTION: A pharmaceutical composition for the treatment of sepsis comprises a tetrahydroisoquinoline-based compound represented by the formula 1 and 2, and a pharmaceutically acceptable salt or prodrug thereof as an effective ingredients. In formulae, X1, X2, X3 and X4 are each independently selected from the group consisting of H, halogen, C1-4 alkyl, hydroxy and C1-4 alkoxy; Y is one or more substituted phenyls by substituents selected from the group consisting of H, C1-4 alkyl and C1-4 alkoxy; one or more substituted or non-substituted naphthyl by substituents selected from the group consisting of H, C1-4 alkyl, hydroxy and C1-4 alkoxy; and k is an integer of 1 to 3.