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ACETYLCYSTEINE-CONTAINING ORAL FORMULATION IN WHICH UNPLEASANT TASTE AND ODOR OF ACETYLCYSTEINE IS MASKED BY CYCLODEXTRIN
ACETYLCYSTEINE-CONTAINING ORAL FORMULATION IN WHICH UNPLEASANT TASTE AND ODOR OF ACETYLCYSTEINE IS MASKED BY CYCLODEXTRIN
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机译:乙酰半胱氨酸掩盖令人讨厌的气味和气味的含乙酰半胱氨酸的口服制剂
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摘要
PURPOSE: An oral formulation containing an acetylcysteine-cyclodextrin inclusion compound is provided. In the formulation, the addition of cyclodextrin masks the unpleasant taste and odor of acetylcysteine, the use of a pH controller improves the stability of the formulation. The formulation is simply manufactured, easily administered and has improved stability. CONSTITUTION: The oral formulation comprises: 0.1 to 70% by weight of an acetylcysteine-cyclodextrin inclusion compound containing acetylcysteine and cyclodextrin in a weight ratio of 1:1 to 6; and 0.1 to 10% by weight of a pH controller, 0.1 to 10% by weight of a thickener, 0.1 to 50% by weight of a sweetener or 0.1 to 10% by weight of a flavoring agent. The pH of the formulation is maintained in the range of 6 to 7.5. The cyclodextrin is one or more selected from the group consisting of -cyclodextrin, -cyclodextrin, -cyclodextrin and cyclodextrin derivatives. The pH controller is selected from the group consisting of citric acid, sodium citrate, succinic acid, sodium succinate, dibasic sodium phosphate, sodium phosphate and sodium hydroxide.
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