PHYTOESTROGENIC COMPOSITION CONTAINING GLYCYRRHIZAE RADIX EXTRACT OR ISOLIQUIRITIN USEFUL FOR HORMONE REPLACEMENT THERAPY AND PREVENTION AND TREATMENT OF BREAST CANCER

摘要

PURPOSE: A phytoestrogenic composition containing a Glycyrrhizae Radix extract or isoliquiritin having potent phytoestrogenic activity is provided. The composition exhibits phytoestrogenic properties, inhibits the activity of bisphenol A as an endocrine disrupting substance and suppresses proliferation of cancer cells including breast cancer cells and is thus used for hormone replacement therapy and prevention and treatment of breast cancer. CONSTITUTION: The phytoestrogenic composition contains a Glycyrrhizae Radix extract or isoliquiritin as an effective ingredient and is used for prevention and treatment of osteoporosis, cardiac and circulatory disorders, menopause symptoms or cancer. The Glycyrrhizae Radix extract is prepared by extracting in an organic solvent selected from the group consisting of C1-4 alcohol, C1-4 aqueous alcohol solution, ethyl acetate, trichloromethyl and hexane. The C1-4 alcohol is methanol or ethanol. A food composition for treatment of the symptoms of menopause and prevention of cancer contains 0.1 to 50% by weight of the organic solvent extract of Glycyrrhizae Radix extract, based on the total weight of the food composition.