PYRAZOLE DERIVATIVE HAVING ANTIMICROBIAL AND INSECTICIDAL ACTIVITY AND PREPARATION METHOD THEREOF

摘要

PURPOSE: A pyrazole derivative and a preparation method thereof are provided, thereby preparing the pyrazole derivative having antimicrobial and insecticidal activity under mild condition. CONSTITUTION: The pyrazole derivative is represented by the formula (2), wherein R1 is hydrogen, C1-C5 lower alkyl, C1-C5 lower haloalkyl, aryl, amino, alkylamino, hydroxy or halogen atom; R2 is hydrogen, C1-C5 lower alkyl, C1-C5 lower haloalkyl, aryl, pyridinyl, amino, alkylamino or halogen atom; and Nu is hydrogen, heterocyclic compound such as pyrrole, pyrazol, imidazol, piperazine, morpholine and pyrrolidine, aryl, hydroxy, amino, alkylamino or halogen atom. The method for preparing the pyrazole derivative of the formula (2) comprises nucleus substitution of a compound of the formula (1) with a nucleophilic substituent of the formula (3) in an organic solvent in the presence of base, wherein X is halogen, and Y is hydrogen or alkali metal such as sodium and potassium.