METHOD FOR PREPARING TARAXINIC ACID HAVING IMPROVED INHIBITING ACTIVITY TO VARIOUS CANCERS, AND CELL DIFFERENTIATION INDUCING ACTIVITY FROM TARAXACUM COREANUM NAKAI AND ANTICANCER AGENT CONTAINING TARAXACI ACID AS EFFECTIVE INGREDIENT

摘要

PURPOSE: A method for preparing taraxinic acid from Taraxacum coreanum nakai and an anticancer agent containing taraxinic acid as an effective ingredient are provided, which taraxinic acid has improved inhibiting activity to various cancers, and cell differentiation inducing activity Therefore, taraxinic acid can be useful for prevention or treatment of cancer. CONSTITUTION: The method for preparing taraxinic acid of the formula(1) from Taraxacum coreanum nakai comprises the steps of: (1) extracting Taraxacum coreanum nakai with alcohol; (2) extracting the extract of step (1) with dichloromethane; (3) extracting the extract of step (2) with ethyl acetate; (4) subjecting the extract of step (3) to the column to isolate taraxinic acid beta-glucopyranosyl ester; and (5) hydrolysis of the isolated taraxinic acid beta-glucopyranosyl ester, wherein the alcohol is selected from methanol, ethanol, propanol and butanol; the column is silica gel and Sephadex columns. The anticancer agent contains 1 to 50 mg/kg of the taraxinic acid as an effective ingredient, wherein the cancer is selected from leukemia, colon cancer, liver cancer and lymphoma.