PURPOSE: Provided are cDNA encoding rabbit prothrombin kringle-2 and the amino acid sequence deduced therefrom. The cDNA sequence is expressed by the expression system in a recombinant E.coli, and rabbit prothrombin kringle-2 produced thereby is effectively used for treatment of rheumatoid disease or cancer, as well as diseases caused by a thrombus. CONSTITUTION: cDNA encoding rabbit prothrombin kringle-2 is obtained by infecting Bacillus Calmette-guerin(BCG) into a New zealand white rabbit; treating the serum of the rabbit with lipopolysaccharide(LPS); and separating the cDNA encoding rabbit prothrombin kringle-2.
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