Acid compounds with antifungal activity in human and veterinary applications

摘要

The present invention relates to compounds of formula (II): EMI ID = 2.1 and pharmaceutically acceptable acid addition salts thereof:;R ₁ is methyl by chlorine, fluorine or trifluoromethyl and;;R ₂ is hydrogen, chlorine, fluorine or trifluoromethyl;;Z is CH or N;;R ₃ , R ₄ and R ₅ are the same or different and are hydrogen or C ₁ -C ₄ alkyl, provided that when R ₃ is hydrogen, R ₄ is different from R ₅ ;;X is O or S;;R ₆ is C ₁ -C ₅ polyfluoroalkyl containing two or more fluorine atoms and any other halogen selected from chlorine and bromine;;The compounds of formula (II) have antifungal activity for human and veterinary use.