Method for Extraction, Isolation and Identification of trans-Resveratrol and Its Derivatives with Anticarcinogenic and Antimutagenic Activity from Paeonia lactiflora Seeds

摘要

PURPOSE: A method for extracting resvedratrol and derivatives thereof having high anticancer and antimutagenic effect from a Paeoniae radix seed is provided. Whereby, the compound can be used for a medicine for prevention and treatment of cancer and functional food material. CONSTITUTION: This resvedratrol and derivatives thereof are extracted by the process consisting of: removing grease from dried Paeoniae radix seed powder by adding n-hexane; concentrating under reduced pressure at room temperature after adding methanol to the defatted Paeoniae radix seed; obtaining an extract by column chromatography; and recrystallizing after separating using a sepadex LH-20 and fraction-high speed liquid chromatography.