RECEPTOR BODY SPECIFICALLY BINDING LIGAND TIE-2, ISOLATED NUCLEIC ACID MOLECULE, PLASMID, PHARMACEUTICAL COMPOSITION AND METHOD FOR PREVENTION OR ATTENUATION OF NEOVASCULARIZATION IN MAMMALS

摘要

FIELD: genetic engineering, medicine. SUBSTANCE: invention relates to the prepared receptor body that is able to bind specifically ligand TIE-2 that comprises extracellular moiety of receptor TIE-2 fused with constant region of human immunoglobulin. Invention proposed plasmid vTIE-2/receptor body containing nucleic acid for expression of receptor body. Pharmaceutical composition contains effective amount of receptor body TIE-2 that is used in method for prevention or attenuation of neovascularization in mammals. Invention provides carrying out diagnosis and treatment of disease concerning endothelial cells comprising receptors TIE-2. Invention provides the development of diagnostic systems for identification of agonist or antagonists of receptor TIE-2. Invention relates specifically to genes encoding tyrosine kinase receptors and can be used for diagnosis. EFFECT: valuable properties of receptor body. 6 cl, 12 dwg, 12 ex