HORMONAL OR ANTI-HORMONAL STEROID COMPOUNDS, METHODS FOR THERAPEUTIC EFFECT, METHOD FOR PREPARING COMPOUNDS

摘要

FIELD: organic chemistry, steroids, medicine.;SUBSTANCE: invention relates to new steroid of the general formula (I); that elicit as effective antagonists of progestins and mixed or incomplete agonists of progestin wherein R¹ means (R²R³N(O)_r)- wherein r = 0,1; each among R² and R³ means independently hydrogen atom (H), (C₁-C₆)-alkyl; or R¹ means; wherein q = 0, 1; Y means (CH₂)_m- wherein m = 1, 2, 3, 4, 5; or R¹ means (C₁-C₆)-alkyl-CO-; R¹² means hydrogen atom (H); X means oxygen atom (O) or; wherein -(CH₂)_m- wherein m = 2; R⁶ means hydrogen atom (H), (C₁-C₆)-alkyl, (C₂-C₆)-alkenyl, (C₂-C₆)-alkynyl possibly substituted with OH or OCHO; S = 0, 1; each among R⁸ and R⁹ represents independently hydrogen atom (H), OH, (C₁-C₆)-alkyl, R¹⁰CO wherein R^10' means hydrogen atom (H), (C₁-C₆)-alkyl. Compounds of the formula (I) are useful for treatment of fibromas, endometriosis, in hormone-substitution therapy and for regulation of fertility.;EFFECT: improved preparing and therapeutic effect methods.;16 cl, 4 tbl, 16 ex