use of imidazole derivatives for the treatment of angiotensin receptors at1 and complaints which are involved in at2 these compounds, their production, use as medicinesand pharmaceutical compositions containing it

摘要

Use of tetra-substd. imidazole derivs. of formula (I), their enantiomers and diastereomers and their acid and base addn. salts, to treat disorders arising from abnormal stimulation of angiotensin II receptors AT1 and AT2, is new. R1 = 1-6C alkyl, alkylthio, alkoxy, aryl, arylthio, aryloxy or aryl(1-6C)alkyl; R2 = -S-R, -O-R, -C(OH)(R)-COOH; halo; or -C(=O)Z; R = 1-8C alkyl, 2-8C alkenyl, 3-6C cycloalkyl or aryl (all opt. substd.); Z = OH, alkoxy or carboxy; R3 = carboxy, acyl halo, 1-8C alkyl, 2-8C alkenyl or alkylthio, aryl, aryl(1-6C)alkyl or aryl(2-6C)alkenyl; R4 = -(CH2)ml-COOR14, -(CH2)ml-CONHR14, -(CH2)ml-CN, -SO2-NH-SO2-R14, -NH-SO2-R14, -PO3R14, SO2NHSO2NR14R15, -SO2NHSO2N(-CH2-CH2-)2D, -SO2-W-R14, etc.; m1 = 0-4; D = O or S; W = -NR15-, -NH-CO-, -NH-CO-O-, -N=CH-N-R15-, or -NH-CO-NR15-; R14, R15 = H, 1-8C alkyl, 2-8C alkenyl, 3-6C cycloalkyl or aryl; or NR14R15 = pyrrolyl, pyrrolinyl, pyrrolidinyl, piperazinyl, alkylpiperazinyl, phenylpiperazinyl, morpholinyl or indolinyl; alkyl radicals are opt. interrupted by one or more heteroatoms (O, N or S); S atoms are opt. oxidised to sulphone or sulphoxide.