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USE OF CYCLODEXTRINE FOR MODULATED GENE EXPRESSION WITH REDUCED IMMUNOSTIMULATION
USE OF CYCLODEXTRINE FOR MODULATED GENE EXPRESSION WITH REDUCED IMMUNOSTIMULATION
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机译:环糊精在调节基因表达和减少免疫刺激中的应用
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摘要
The present invention provides a method of reducing the immunostimulatory effects of certain phosphorothioate oligonucleotides used to treat pathogen-mediated disease states and other medical conditions. Immunostimulatory effects of phosphorothioate oligonucleotides are reduced in accordance with the method of the invention by administering the phosphorothioate oligonucleotide in a therapeutic formulation which includes at least one cyclodextrin to a mammal afflicted with the disease or condition being treated. The immune response of the mammal is also monitored in the method of the invention.
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