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Treatment of red blood cells for the inactivation of virien by the use of pathalocyanine and red light
Treatment of red blood cells for the inactivation of virien by the use of pathalocyanine and red light
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机译:通过使用酞菁和红光治疗红细胞以灭活病毒
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PCT No. PCT/US96/17528 Sec. 371 Date Sep. 1, 1998 Sec. 102(e) Date Sep. 1, 1998 PCT Filed Nov. 4, 1996 PCT Pub. No. WO97/16966 PCT Pub. Date May 15, 1997Disclosed are two processes. The first process involves treating a red blood cell-containing composition to inactivate an extracellular or intracellular virus which may be present in said red blood cell-containing composition by subjecting said red blood cell-containing composition to a virucidally effective amount of a phthalocyanine and red light, wherein the improvement involves (i) determining the action spectrum of said phthalocyanine for causing inactivation of said virus; (ii) determining the action spectrum of said phthalocyanine for causing red blood cell damage; (iii) comparing (i) and (ii), and, if (i) and (ii) are not identical then determining the wavelength at which the largest favorable difference exists between (i) and (ii); (iv) providing a red light source emitting red light only in 10 nm in either direction of the wavelength determined in (iii); and then (v) subjecting said red blood cell-containing composition to said virucidally effective amount of said phthalocyanine and said provided red light source. In a preferred embodiment, the phthalocyanine is Pc 4, which has the formula: HOSiPcOSi(CH3)2(CH2)3N(CH3)2. The second process involves transfusing red blood cells to a patient in need thereof by withdrawing red blood cells from a donor, subjecting the red blood cells to the first process and transfusing the red blood cells to said patient.
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