New vitamin D analogs useful in the manufacture of medicament or in cosmetic composition for the treatment of e.g. acne, psoriasis, collagen diseases, skin aging

摘要

Vitamin D analogs (I), their optical and geometric isomers and salts are new. Vitamin D analogs of formula (I), their optical and geometric isomers and salts are new. A-Q = unsubstituted alkyne or alkene bond, -CH2-O- bond, -CH2-S- bond or -CH2-CH2- bond; B-T = A-Q or -CH2-NR6- bond; R3 = E or -CF2R5; E = linear or branched 1-5C alkyl; R1 and R2 = H or R3; R5 = F, H or CF3; R7 and R8 = H or G; G = linear or branched 1-6C alkyl; R4 = R7 or -CF2R5; R4+R4 = J, or a saturated heterocycle (preferably pyrrolidine, piperidine (both substituted on N by R7) furan or pyran); j = a saturated 4-7C ring; and R6 = R7 or -C(O)R8. Independent claims are included for the following: (1) a pharmaceutical composition comprising at least one (I) (0.001 - 5) wt.% and a carrier; and (2) a cosmetic composition comprising at least one (I) (0.001 - 3) wt.% and a carrier.