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Production of a vector for active molecules, e.g. fatty acids or antioxidants for biomedical applications, involves polycondensation of a diamine such as ornithine with glutaraldehyde at near-neutral pH
Production of a vector for active molecules, e.g. fatty acids or antioxidants for biomedical applications, involves polycondensation of a diamine such as ornithine with glutaraldehyde at near-neutral pH
A method for the production of a vector for active molecules by polycondensation of (A) a diamine in which the amino groups are separated by at least 4 carbons with (B) glutaraldehyde involves carrying out the reaction at pH 6.5-7.5. A method for the production of a vector for active molecules for use in biomedical applications involves (a) diluting a monomer containing at least two NH2 groups separated by at least 4 carbons with water, (b) adjusting to pH 6.5-7.5, (c) adding glutaraldehyde, (d) reacting by polycondensation with imine formation and (e) working up the polymer obtained, i.e. poly-(monomer-G), where G represents reduced glutaraldehyde. An Independent claim is also included for vectors as above, comprising poly-(ornithine-G), poly-(L-lysine-G) or poly-(citrulline-G) (i.e. poly-(monomer-G)) grafted with active molecules such as fatty acids, antioxidants, vitamins, hormones, medicaments or neuro-transmitters to provide bacteriostatic, anti-allergenic, anti-parasite, anti-predator, antifungal, anti-inflammatory or immunomodulant activity.
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