New antimicrobial peptide papillosin, useful for treating infections by Gram positive or negative bacteria or fungi, in humans, animals or plants

摘要

An isolated peptide (I), designated papillosin, and its derivatives and fragments are new. Isolated peptide of formula (I), designated papillosin, and its derivatives and fragments are new. Gly-Phe-Trp-Lys-Lys-Val-Gly-Ser-Ala-Ala-Trp-Gly-Gly-Val-Lys-(Ala) 3-Lys-Gly-Ala-Ala-Val-Gly-Gly-Leu-Asn-Ala-Leu-Ala-Lys-His-Ile-Gln (I) Independent claims are also included for the following: (1) isolated polypeptide (II) that includes (I); (2) isolated polynucleotide (III) that encodes (I) or (II); (3) cloning and/or expression vector that contains (III); (4) host organism that contains a vector of (3) or (III); (5) plant cell resistant to microbial disease that contains (III) or expresses (I) or (II); and (6) plant containing at least one cell of (5). ACTIVITY : Antibacterial; Fungicide; Plant Antibacterial; Plant Antifungal. The minimum bactericidal concentration of (I), in MicroM, was 0.125-0.25 against M. luteus; 0.5-1 against S. aureus and 0.25-0.5 against E. coli DH5alpha . MECHANISM OF ACTION : Bacteriolysis.