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Homogeneous solutions comprising a cyclosporin, a triglycerol monoester of a fatty acid, polyethylene glycol and a non-ionic surfactant
Homogeneous solutions comprising a cyclosporin, a triglycerol monoester of a fatty acid, polyethylene glycol and a non-ionic surfactant
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机译:均相溶液,包含环孢菌素,脂肪酸的甘油三酸酯,聚乙二醇和非离子表面活性剂
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摘要
A pharmaceutical composition suitable for oral administration in the form of a homogeneous solution which on exposure to water or gastrointestinal fluids forms an emulsion having a particle size of less than 5 microns. The solution comprises: SL LI(a) a pharmaceutically effective amount of a cyclosporin, in particular Cyclosporin A LI(b) a carrier medium comprising a triglycerol monoester of a fatty acid having from 6 to 30 carbon atoms or mixtures thereof, LI(c) polyethylene glycol, LI(d) a non-ionic surfactant having a hydrophilic lipophilic balance (HLB) greater than 10, and LI(e) optionally, a viscosity reducing agent. /SL The preferred carrier medium is triglycerol monooleate. Examples of the viscosity reducing agent are glycerol monocaprylate and glycerol monooleate. The composition may be formulated as a drinking solution or as a hard or soft capsule.
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