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SOLID PHARMACEUTICAL PREPARATION COMPOSITION COMPRISING LIQUID OR SEMI-SOLID ACTIVE INGREDIENT AND POROUS CELLULOSE AGGREGATE PARTICLE
SOLID PHARMACEUTICAL PREPARATION COMPOSITION COMPRISING LIQUID OR SEMI-SOLID ACTIVE INGREDIENT AND POROUS CELLULOSE AGGREGATE PARTICLE
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机译:包含液体或半固体活性成分和多孔纤维素聚集颗粒的固体药物制剂组合物
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摘要
PROBLEM TO BE SOLVED: To obtain a solid pharmaceutical preparation composition preventing bleeding of a liquid ingredient and having good tableting and disintegrating properties in a solid pharmaceutical preparation comprising the liquid or semisolid active ingredient by using a porous cellulose aggregate having a large intraparticle pore volume.;SOLUTION: This solid pharmaceutical preparation composition is characterized as comprising an active ingredient which is liquid or semisolid at normal temperature and the porous cellulose aggregate. Furthermore, the porous cellulose aggregate has a secondary aggregate structure in which cellulose primary particles are aggregated and ≥0.265 cm3/g intraparticle pore volume, contains I type crystals, has 30 μm average particle diameter, 1.3-20 m2/g specific surface area and 44° angle of repose and disintegrates in water.;COPYRIGHT: (C)2005,JPO&NCIPI
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