CARDIAC HYPERTROPHY/CARDIAC FAILURE MOUSE BY TRANSFERRING GENE OF HEPATITIS C VIRUS

摘要

PROBLEM TO BE SOLVED: To attain the smooth supply of mice as a Homo sapiens disease model mouse for elucidation of the mechanism of pathogenesis, prophylaxis, diagnosis, treatment, or the like, of cardiac hypertrophy/cardiac failure caused by HCV (hepatitis C virus), further can widely and repeatedly utilize the mouse as an experimental material of cardiac failure and cardiac hypertrophy caused by HCV and can promote the study relating to the elucidation of the mechanisms of pathogenesis, prophylaxis, diagnosis, treatment, or the like, of cardiac hypertrophy/cardiac failure caused by HCV and cell level of studies thereon.;SOLUTION: An HCV gene is transferred into a cardiac hypertrophy/cardiac failure mouse so that (1) at 24 weeks of age, abnormal cardiac function cannot clearly be observed and (2) at 48 weeks of age, decrease of systolic arterial pressure, increase in heart weight and weight ratio of heart/body, increase in ventricular end-systolic volume, increase in left ventricular end-diastolic volume, decrease in left ventricular ejection fraction and drop of dp/dt may be observed, respectively.;COPYRIGHT: (C)2005,JPO&NCIPI