IMP dehydrogenase and its use in the identification of fungicidal active compounds

摘要

Method for identifying fungicides (Q) from the ability of test compounds to inhibit specifically the biological activity of a peptide (I) that has inosine monophosphate (IMP) dehydrogenase (IMPDH) activity. ??Independent claims are also included for: ??(1) Fungicides identified by the new method; ??(2) Nucleic acid (II) that encodes IMPDH from a phytopathogenic fungus; ??(3) DNA construct that contains (II); ??(4) Vector that contains (II) or the construct of (3); ??(5) Host cell that contains (II), the construct of (3) or the vector of (IV); ??(6) Polypeptide (Ia) from phytopathogenic fungi having IMPDH activity and encoded by (II); ??(7) Antibodies that bind specifically to (Ia); ??(8) Methods for preparing (II); ??(9) Method for preparing (Ia) by culturing cells of (5) or by expressing (II) in an in vitro system; and ??(10) Method for identifying compounds that alter expression of (Ia).