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Hybrid hepatocyte growth factor gene with high gene expression efficiency and simultaneously expressing two variants of hepatocyte growth factor
Hybrid hepatocyte growth factor gene with high gene expression efficiency and simultaneously expressing two variants of hepatocyte growth factor
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机译:具有高基因表达效率并同时表达两种肝细胞生长因子变异体的杂交肝细胞生长因子基因
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摘要
The present invention relates to a hybrid Hepatocyte Growth Factor (HGF) gene which is prepared by inserting an inherent or foreign intron between exons 4 and 5 in HGF cDNA, which has a base sequence of SEQ ID NO: 2. The gene has high expression efficiency and simultaneously expresses two heterotypes of HGF and dHGF (deleted variant HGF). Further the gene may be used for treating or preventing ischemic or liver diseases.
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机译:杂合肝细胞生长因子(HGF)基因技术领域本发明涉及杂合肝细胞生长因子(HGF)基因,其通过在HGF cDNA的外显子4和5之间插入固有或外来内含子而制备,其具有SEQ ID NO:2的碱基序列。该基因具有高表达并同时表达HGF和dHGF的两种异型(缺失的HGF变体)。此外,该基因可以用于治疗或预防局部缺血或肝脏疾病。
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