C5-SUBSTITUTED PYRIMIDINE OR N6-SUBSTITUTED PURINE-2'-DEOXYNUCLEOTIDE DERIVATIVE AND METHOD FOR SYNTHESIZING NUCLEIC ACID USING THE SAME

摘要

PROBLEM TO BE SOLVED: To provide a C5-substituted deoxycytidine derivative or an N6-substituted deoxyadenosine derivative enzymically synthesizing modified DNAs especially required for DNA analysis with a DNA chip and to provide a method for synthesizing nucleic acid using the same.;SOLUTION: The C5-substitured deoxycytidine derivative is characterized in that the derivative is represented by general formula {wherein, R denotes an NHX; and X denotes a hydrogen atom, an alkynyl group, an alkenyl group, an alkynyl group or an aryl group, a COCF₃ group, a COCH₃ group, a carbonylmethylimidazole group, a CH(=NH)NH₂, a biotinyl group, various amino acids bound through amide bonds or a (CH₂)₂N[(CH₂)₂NH₂]₂ group}.;COPYRIGHT: (C)2005,JPO&NCIPI