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Methods for using isogenic human cancer cells for high-throughput screening and drug discovery
Methods for using isogenic human cancer cells for high-throughput screening and drug discovery
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机译:使用等基因人类癌细胞进行高通量筛选和药物发现的方法
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摘要
A strategy for drug-screening is based on cells that are isogenic except for a gene of interest. Each cell can be tranfected with a vector that encodes a different fluorescent protein that can be differentially detected to monitor cell growth. Co-culture of both cells allows facile screening for compounds with selective toxicity towards a gene of interest. The drug screening is broadly applicable for mining therapeutic agents targeted to specific genetic alterations responsible for cancer development.
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