Regulation of leukocyte endothelial interactions after ischemia

摘要

The present invention relates to methods and compositions for the reduction or prevention of damage to tissue or organs, e.g., the brain, caused by reperfusion following ischemia, e.g., stroke. The present invention also provides methods and compositions for the reduction of the size of infarcts resulting from ischemia and/or reperfusion, in a subject, by administering a P-selectin antagonist. The invention further provides methods for modulating, e.g., attenuating, leukocyte rolling, intercellular adhesion, and cell adhesion to blood vessels in a subject by administering soluble P-selectin ligand or fragments thereof, an anti-P-selectin ligand antibody, or an anti-P-selectin antibody. The invention also provides methods for identifying compounds capable of reducing or preventing damage to tissue or organs caused by ischemic disorders and reperfusion injury.