Using the isolated nucleic acid molecule encoding a bacterial uracil phosphoribosyl transferase enzyme and bacterial uracil transporter proteins, and cells transformed with said nucleic acid molecule

摘要

Disclosed herein are novel polynucleotides encoding one of a uracil transport protein and a uracil phosphoribosyl transferase, each being derived from Salmonella typhimurium. The disclosed uracil phosphoribosyl transferase protein is useful in sensitizing human cancer cells to treatment with anti-cancer agents such as 5-Fluorouracil.