Heparin-binding epidermal growth factor-like growth factor gene function modified animals, screening methods, embryonic stem cells, as well as therapeutic drugs and heart failure / or prevention

摘要

And a method for manufacturing the non-human animal having a DNA sequence of heparin-binding epidermal growth factor-like growth factor gene that has been introduced such mutations alter the function of heparin-binding epidermal growth factor-like growth factor gene. Non-human embryonic stem cells with a DNA sequence of the heparin-binding epidermal growth factor-like growth factor gene is a mutated so as to alter the function of the heparin-binding epidermal growth factor-like growth factor gene. A method for screening a therapeutic agent and / or heart failure prevention. And / or therapeutic agents heart failure prevention.