Use and rheumatoid arthritis diagnostic immune reagents as rheumatoid arthritis for marker

摘要

PROBLEM TO BE SOLVED: To enable the highly accurate diagnosis of chronic articular rheumatism (RA) by using an anti-aldolase A antibody as a marker for RA. ;SOLUTION: An immune reagent for diagnosing RA is not especially limited in its form if aldolase A or modified aldolase A generating the antigen-antibody reaction with an anti-aldolase A antibody present in body fluids of an RA patient to detect the anti-aldolase A antibody is used but aldolase A or modified aldolase A is pref. used in a form supported on an insoluble carrier. The usable insoluble carrier is not especially limited in its material and shape if it is a carrier insoluble in a solvent in an antigen-antibody reaction system. As a fixation method for aldolase A or modified aldolase A, a known method such as a physical adsorbing method or the like can be used without limitation. The immune reagent for diagnosing RA is brought into contact with a specimen and the antigen-antibody reaction of the anti-aldolase A antibody and supported aldolase A is detected to diagnose RA.;COPYRIGHT: (C)1999,JPO