DYNAMICS OF ACTIVATION OF CELLULAR IMMUNITY AND INFLAMMATION MARKERS IN PATIENTS WITH RHEUMATOID ARTHRITIS, WITH THE USE OF LOW LEVEL INFRA RED PULSE LASER THERAPY (LL-IRPLT).

摘要

This study is an investigation of the influence of LLP-IR-LT (λ=890 nm), on the activation markers of the immunity system in sera patients with RA. We have studied 137 patients with proved RA forming elementary group and 29 chosen at random representing the control - placebo group. The levels of soluble receptors and neopterin in sera were examined in 53 RA patients from the elementary and in 12 from the control group. These patients were subjected to dynamic determination of soluble TNFα receptors (sTNF- αR), sIL-2R and neopterin by immunoenzym method; and of C-reactive protein (CRP) by radioimmunodiffusion or by immunoenzym method. Due to the LLP-IR-LT therapy, a significant decrease of previously increased level of the sTNF- αR (p<0.01), of neopterin (p<0.05), and of sIL-2R (p<0.05) was registered. Also a significant decrease of previously increased CRP (p<0.01) concentration was registered. Placebo group demonstrates significantly increased level of sTNF-αR-(p<0.01) and CRP-(p<0.01) after LLP-IR-LT. The obtained results represent a pathophysiological basis of LL-IRPLT application in RA, which is connected with the suppression of the functional activity of previously activated macrophages (the main source of the neopterin and sTNFaR), while the suppression of activated T lymphocytes (main source of the sIL-2R).