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Ribozymes targeting retroviral packaging sequences, expression constructs thereof, and recombinant retroviruses containing such constructs
Ribozymes targeting retroviral packaging sequences, expression constructs thereof, and recombinant retroviruses containing such constructs
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机译:靶向逆转录病毒包装序列的核酶,其表达构建体以及包含此类构建体的重组逆转录病毒
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摘要
The present invention concerns an oligonucleotide compound, which comprises a ribozyme targeted to the GUA target site at nucleotide 5849 of the HIV-1 SF-2 isolate or a corresponding target site of other HIV-1 isolates. The invention also relates to transfer vectors comprised of RNA or DNA or a combination thereof which on transcription give rise to said compound, to cells comprising a nucleotide sequence which is, or on transcription gives rise to, said compound and to pharmaceutical compositions containing said compound or said transfer vector. IMAGE
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