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RIBOZYMES TARGETING THE RETROVIRAL PACKAGING SEQUENCE EXPRESSION CONSTRUCTS AND RECOMBINANT RETROVIRUSES CONTAINING SUCH CONSTRUCTS
RIBOZYMES TARGETING THE RETROVIRAL PACKAGING SEQUENCE EXPRESSION CONSTRUCTS AND RECOMBINANT RETROVIRUSES CONTAINING SUCH CONSTRUCTS
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机译:以核糖酶为靶标的逆转录包装序列表达构建体和包含这种构建体的重组逆转录病毒
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摘要
The present invention concerns an oligonucleotide compound, which comprises a ribozyme targeted to the GUA target site at nucleotide 5849 of the HIV-1 SF-2 isolate or a corresponding target site of other HIV-1 isolates. The invention also relates to transfer vectors comprised of RNA or DNA or a combination thereof which on transcription give rise to said compound, to cells comprising a nucleotide sequence which is, or on transcription gives rise to, said compound and to pharmaceutical compositions containing said compound or said transfer vector. IMAGE
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