PURPOSE: To obtain a low-toxic medicine for dry vagina free from side effects, acting on exocrine gland, esp. capable of promoting the secretion of various secretions from the vagina and vulva through stimulating muscarinic M3-type receptor, containing, as active ingredient, a specific spiroxathiolanequinuclidine derivative. ;CONSTITUTION: This medicine contains, as active ingredient, a compound (or an acid-added salt thereof) of formula I (R1 and R2 are each H, an alkyl, cyclopentyl, cyclohexyl, aryl or diarylmethylol, or aryl-substituted alkyl) [e.g. 2-methylspirow(1,3-oxathiolane5,3')quinuclidine hydrochklorid cis-form of formula II]. The compound of formula is obtained, for example, by reaction of 3- hydroxy-3-mercaptomethylquinuclidine with a compound of formula R1CO-R2. The dose of this medicine (in terms of the active ingredient) is pref. 1-1000mg a day per adult.;COPYRIGHT: (C)1996,JPO
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