Substrate Cdc7-ASK kinase complex of the kinase complex, and an antibody specific and a candidate substance Cdc7-ASK kinase inhibitory ability using them to said substrate

摘要

The present invention provides an indicator of the MCM that are substrates for Cdc7-ASK kinase complex, the level of phosphorylation in the phosphorylation site, the phosphorylation activity measurement method of Cdc7-ASK kinase complex. It is also possible on the basis of the measurement method, and to evaluate the effect on the kinase activity of Cdc7-ASK kinase complex of the test compound. Compounds that inhibit the kinase activity is useful as anticancer agents with excellent specificity for cancer.