Screening of natural product samples for novel therapeutic compounds such using capillary electrophoresis

摘要

(57) Abstract The chemical compound which is connected to the specific molecule which you observe strongly is disclosed, the method where from the natural sample component simultaneously it is divided and is sorted and. This way the ligand which is separated anew comes latently for remedy or the chemical compound for diagnosis well and becomes candidacy. The natural sample to be connected the latent target molecule first, then it is introduced into capillary cataphoresis (CE). Can modify that usual shifting field with CE, or the electric charge which exists in the natural sample which is connected to the target molecule which is added the chemical compound which is done (or neuter) by changing the electric charge anti- mass ratio, peak form or the territory cause change makes. To detect by watching the movement of the target molecule simply it is possible compound form, to the period of cataphoresis. Every new ligand which is connected to the target molecule comes, for remedy or the chemical compound for diagnosis well and becomes candidacy. Generally exists the ligand which weak connection disturbs is not detected inside the crude extract. The minute natural ligand same as the ligand which electric charge is done, can be identified at the time of connection comparison experimenting of the competitive molecule which known electric charge is done.