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Benzothiazepine and benzothiadiazepine derivatives with ileal bile acid transport (IBAT) inhibitory activity for the treatment of hyperlipidemia
Benzothiazepine and benzothiadiazepine derivatives with ileal bile acid transport (IBAT) inhibitory activity for the treatment of hyperlipidemia
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机译：具有回肠胆汁酸转运（IBAT）抑制活性的苯并噻氮平和苯并噻二氮杂卓衍生物用于治疗高脂血症
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摘要
The present invention relates to compounds of formula (I) wherein RSUPv/SUP, RSUP1/SUP, RSUP2/SUP, RSUPx/SUP, RSUPy/SUP, M, RSUPz/SUP, v, RSUP3/SUP, RSUP4/SUP, RSUP5 /SUPand RSUP6 /SUPare as defined within; pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described.
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机译：本发明涉及式（I）的化合物，其中R v ，R 1 ，R 2 ，R x ，R y ，M，R z ，v，R 3 ，R 4 ，R 5 和R 6 在其中定义;药学上可接受的盐，溶剂化物，这些盐的溶剂化物及其前药，以及它们作为回肠胆汁酸转运（IBAT）抑制剂用于治疗高脂血症的用途。还描述了它们的制造方法和包含它们的药物组合物。
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