Proteins with cell death regulatory function and cell migration regulation

摘要

The present invention relates to a protein having a cell migration regulating function and a cell death regulating function of a nerve cell and the like, and a DNA encoding such a protein. Substances that control cell migration and / or cell death and promote or suppress cell migration and / or cell death regulatory functions using proteins that regulate cell migration ability and cell death and DNAs encoding them. It provides a screening method and the like. S-FILIP, L-FILIP, and S-FILIP, which interact with the actin-binding protein Filamin 1, negatively regulate cell migration by promoting the degradation of such a filamin 1, and are involved in regulating cell death. h-FILIP cDNA was isolated, and the entire nucleotide sequence and amino acid sequence were determined.