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FHOS-interacting proteins and use thereof

机译：FHOS相互作用蛋白及其用途

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摘要

Protein complexes are provided comprising FHOS and one or more proteins selected from the group consisting of GROUP1. Methods of using the protein complexes in diagnosing diseases and disorders are also provided. In addition, the protein complexes are also useful in screening assays for identifying compounds effective in treating and/or preventing diseases and disorders associated with FHOS and its interactors.

机译：提供了包含FHOS和一种或多种选自GROUP 1 的蛋白质的蛋白质复合物。还提供了使用蛋白质复合物诊断疾病和病症的方法。另外，蛋白质复合物还可用于筛选测定中，以鉴定有效治疗和/或预防与FHOS及其相互作用物有关的疾病和病症的化合物。 展开▼

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公开/公告号US2005100966A1

专利类型

公开/公告日2005-05-12

原文格式PDF

申请/专利权人 TAKESHI SAKAMOTO;SHIZU TAKEDA;
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申请/专利号US20040805684

发明设计人 SHIZU TAKEDA;TAKESHI SAKAMOTO;
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申请日2004-03-19

分类号C12Q1/68;G01N33/53;C12N9/64;C07K14/00;

国家 US

入库时间 2022-08-21 22:26:04

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机译：选择至少一个分子，制备组合物，增强个体中细胞外蛋白质降解和/或消除蛋白质，至少部分抑制蛋白质错误折叠和/或跨界介导的作用以至少部分预防和/的方法或治疗疾病，病症和/或感染，以部分除去错误折叠的蛋白质，交联结构和/或蛋白质，以确定是否存在功能异常的蛋白质和/或包含交叉结构的蛋白质和/或肽在水溶液中，以减少和/或预防药物组合物的不良副作用和/或增加蛋白质克的比活性，干扰血液凝结以确定组合物中错折叠的蛋白质和/或交叉结构的数量，确定不同的跨框架结构，确定错误折叠的蛋白质，跨框架或蛋白质的身份，并治疗受试者

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机译：血管抑素结合蛋白，与n末端纤溶酶原片段结合的肽，编码所述蛋白和肽的核酸，包含所述核酸的载体，包含所述载体的重组细胞，与所述蛋白或肽结合的抗体，表达所述抗体的重组细胞，扫描能够与所述蛋白质相互作用的化合物的方法，通过所述方法鉴定的化合物，所述蛋白质，肽或化合物在制备用于治疗与血管生成有关的疾病或病症的药物中的用途以及包含所述蛋白质，肽或化合物的药物制剂。

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