SK3-1B GFP transgenic mouse model for spinocerebellar ataxia and hyperexcitable behavior

摘要

Transgenic animals exhibiting several hallmark features of SK-3 related pathologies, including moderate to severe ataxia, intention tremors and hyperexcitable behavior are provided. This transgenic animal model represents a valuable research tool for testing candidate agents for treatment of individuals diagnosed with SK-3 related pathologies, either prophylactically or after disease onset.