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Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content
Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content
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机译:包含Lewis-X结构和高唾液酸含量的促红细胞生成素同工型的组成
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摘要
Disclosed are immortalized human embryonic retina cells, having a nucleic acid sequence encoding an adenoviral E1A protein integrated into the genome of the cells, and further comprising a nucleic acid sequence encoding an enzyme involved in post-translational modification of proteins, such as a sialyltransferase, wherein said nucleic acid sequence encoding the enzyme involved in post-translational modification of proteins is under control of a heterologous promoter. Methods for producing recombinant proteins from such cells and obtaining such recombinant proteins having increased sialylation are provided as are novel compositions of isoforms of erythropoietin .
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