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Methods of producing erythropoietin isoforms comprising Lewis-X structures and high sialic acid content and compositions of the same
Methods of producing erythropoietin isoforms comprising Lewis-X structures and high sialic acid content and compositions of the same
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机译:产生具有Lewis-X结构和高唾液酸含量的促红细胞生成素同工型的方法及其组成
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摘要
Disclosed are immortalized human embryonic retina cells, having a nucleic acid sequence encoding an adenoviral E1A protein integrated into the genome of the cells, and further comprising a nucleic acid sequence encoding an enzyme involved in post-translational modification of proteins, such as a sialyltransferase, wherein the nucleic acid sequence encoding the enzyme involved in post-translational modification of proteins is under control of a heterologous promoter. Methods for producing recombinant proteins from such cells and obtaining such recombinant proteins having increased sialylation are provided as are novel compositions of isoforms of erythropoietin.
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